About: Pentostatin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Pentostatin
equivalentClass	nodeID://b636980
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Antibiotic Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	Pentostatin
NSC_Code	218321 247520
UMLS_CUI	C0030896
CAS_Registry	53910-25-1 63677-95-2
Accepted_Therapeutic_Use_For	Chronic lymphocytic leukemia; Cutaneous t-cell lymphoma; Hairy cell leukemia
In_Clinical_Trial_For	Chronic lymphocytic leukemia; Graft versus Host disease; Lymphoid malignancies; Non-Hodgkins lymphoma; Renal cell cancer
FDA_UNII_Code	395575MZO7
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug that is used to treat hairy cell leukemia and is being studied in the treatment of other types of cancer. Pentostatin blocks a protein needed for cell growth and may kill cancer cells. It is made by a bacterium. It is a type of adenosine deaminase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39210
PDQ_Closed_Trial_Search_ID	39210
Chemical_Formula	C11H16N4O4
Legacy_Concept_Name	Pentostatin
FULL_SYN	PentostatinPTNCI CovidarabineSYDTPNSC0218321 (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-olSNNCI CovidarabineSYNCI PentostatineSYNCI Co-VidarabineSYNCI Co-vidarabineSYDTPNSC0247520 pentostatinPTNCI-GLOSSCDR0000045190 DCFABNCI DeoxycoformycinSYNCI NipentPTNCI-GLOSSCDR0000618582 CI-825CNNCI NipentBRNCI 2'-DeoxycoformycinSYNCI (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-olSYDTPNSC0247520 PD-81565CNNCI PENTOSTATINPTFDA395575MZO7 PENTOSTATINSYDTPNSC0247520 2'-DeoxycoformycinSYDTPNSC0247520
DEFINITION	A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)NCI
code	C732
sameAs	PENTOSTATIN PENTOSTATIN
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0023987
is someValuesFrom of	nodeID://b658913 nodeID://b661546 nodeID://b663609 nodeID://b663611 nodeID://b673798 nodeID://b682147 nodeID://b692561 nodeID://b698900 nodeID://b698925 nodeID://b702269 nodeID://b702271
is sameAs of	PENTOSTATIN PENTOSTATIN PENTOSTATIN

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