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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nanafrocin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Nanafrocin
UMLS_CUI
  • C0068391
CAS_Registry
  • 52934-83-5
FDA_UNII_Code
  • 8XBV72641V
Contributing_Source
  • FDA
Chemical_Formula
  • C16H14O6
Legacy_Concept_Name
  • Nanafrocin
CHEBI_ID
  • CHEBI:48202
FULL_SYN
  • Nanaomycin ASYNCI
  • (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic AcidSNNCI
  • NANAFROCINPTFDA8XBV72641V
  • OS 3966-ACNNCI
  • NanafrocinPTNCI
DEFINITION
  • A quinone antibiotic isolated from Streptomyces rosa var. notoensis with activity against gram-positive bacteria, mycoplasmas and fungi. Within an organism, nanaomycin A is first reduced by flavin or NADH dehydrogenase then rapidly autooxidized leading to the production of singlet molecular oxygen (O2-). The increase in intracellular O2- results in inhibition of DNA, RNA and cell-wall peptidoglycan synthesis. Further, nanaomycin A may have antineoplastic properties resulting from a reduction in DNA methylation by inhibiting DNA methyltransferase 3B (DNMT3B) and reactivating the tumor suppressor gene RASSF1A.NCI
code
  • C72594
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