About: Enzalutamide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Enzalutamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Enzalutamide
UMLS_CUI
  • C2348174
CAS_Registry
  • 915087-33-1
Accepted_Therapeutic_Use_For
  • Prostate cancer
FDA_UNII_Code
  • 93T0T9GKNU
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 560774
PDQ_Closed_Trial_Search_ID
  • 560774
Chemical_Formula
  • C21H16F4N4O2S
Legacy_Concept_Name
  • Selective_Androgen_Receptor_Modulator_MDV3100
FULL_SYN
  • ENZALUTAMIDEPTFDA93T0T9GKNU
  • EnzalutamidePTNCI
  • XtandiBRNCI
  • MDV3100CNNCI
  • Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-SNNCI
DEFINITION
  • An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.NCI
code
  • C71744
sameAs
http://linked.open...y/mesh/hasConcept
is sameAs of
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 13 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software