About: PVA Microporous Hydrospheres/Doxorubicin Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • PVA Microporous Hydrospheres/Doxorubicin Hydrochloride
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PVA Microporous Hydrospheres/Doxorubicin Hydrochloride
NCI_META_CUI
  • CL376223
PDQ_Open_Trial_Search_ID
  • 574045
PDQ_Closed_Trial_Search_ID
  • 574045
Legacy_Concept_Name
  • PVA_Microporous_Hydrospheres_Doxorubicin_Hydrochloride
FULL_SYN
  • QuadraSphere Microspheres/Doxorubicin HydrochlorideSYNCI
  • PVA Microporous Hydrospheres/Doxorubicin HydrochloridePTNCI
  • HepaSphere Microspheres/Doxorubicin HydrochlorideSYNCI
DEFINITION
  • An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature. Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. When used in tumor vasculature embolization, this preparation may provide more tumor-specific treatment with doxorubicin compared to the systemic administration of doxorubicin, thereby reducing the systemic toxicity of doxorubicin.NCI
code
  • C71149
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