About: Obinutuzumab     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Obinutuzumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Obinutuzumab
UMLS_CUI
  • C2742503
CAS_Registry
  • 949142-50-1
FDA_UNII_Code
  • O43472U9X8
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 570643
PDQ_Closed_Trial_Search_ID
  • 570643
Legacy_Concept_Name
  • Anti-CD20_Monoclonal_Antibody_R7159
FULL_SYN
  • huMAB(CD20)SYNCI
  • OBINUTUZUMABPTFDAO43472U9X8
  • AfutuzumabAQSNCI
  • ObinutuzumabPTNCI
  • Anti-CD20 Monoclonal Antibody R7159SYNCI
  • GA101CNNCI
  • R7159CNNCI
  • RO 5072759CNNCI
DEFINITION
  • A glycoengineered, humanized IgG1 monoclonal antibody with potential antineoplastic activity. Afutuzumab, a third generation type II anti-CD20 antibody, selectivity binds to the extracellular domain of the human CD20 antigen on malignant human B cells. The Fc region carbohydrates of the antibody, enriched in bisected non-fucosylated glycosylation variants, contribute to its higher binding affinity for human FcgammaRIII receptors compared to non-glycoengineered antibodies, resulting in enhanced antibody-dependent cellular cytotoxicity (ADCC) and caspase-independent apoptosis. In addition, modification of elbow hinge sequences within the antibody variable framework regions may account for the strong apoptosis-inducing activity of R7159 upon binding to CD20 on target cells.NCI
code
  • C70741
http://linked.open...y/mesh/hasConcept
is sameAs of
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 40 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software