About: Complement Component-4     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Complement Component-4
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Complement Component-4
UMLS_CUI
  • C0009516
Legacy_Concept_Name
  • Complement_Component-4
FULL_SYN
  • Complement Component-4PTNCI
  • Complement C4SYNCI
  • C4SYNCI
DEFINITION
  • Complement component-4 (1744 aa, ~193 kDa) is part of the complement cascade, which mediates the innate immune response to infection. The full length protein is a precursor that can is secreted as a trimeric molecule containing an alpha, beta and gamma chain. When the complement cascade is initiated, the protein is cleaved. This proteolysis releases both the alpha chain, C4 anaphylatoxin, which stimulates inflammation, and a dimer of the beta and gamma chains, which mediates the interaction between the antigen-antibody complex and other complement components.NCI
DesignNote
  • Human complement component C4 is polymorphic at two loci, C4A and C4B. 13 alleles of C4A and 22 alleles of C4B have been detected. The C4A alleles carry the Rodgers (Rg) blood group antigens while the C4B alleles carry the Childo (Ch) blood group antigens. (SwissProt)
code
  • C70618
sameAs
http://linked.open...y/mesh/hasConcept
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