About: Polymeric Camptothecin Prodrug XMT-1001     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Polymeric Camptothecin Prodrug XMT-1001
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Polymeric Camptothecin Prodrug XMT-1001
UMLS_CUI
  • C2347623
PDQ_Open_Trial_Search_ID
  • 544567
PDQ_Closed_Trial_Search_ID
  • 544567
Legacy_Concept_Name
  • Polymeric_Camptothecin_Prodrug_XMT-1001
FULL_SYN
  • Polymeric Camptothecin Prodrug XMT-1001PTNCI
  • MER-1001CNNCI
  • XMT-1001CNNCI
DEFINITION
  • A polymeric prodrug of camptothecin (CPT) with potential antineoplastic activity. Polymeric camptothecin prodrug XMT-1001 consists of CPT conjugated to the 60-70 kDa, inert, bio-degradable, hydrophilic copolymer poly[1-hydroxymethylene hydroxymethyl formal] (PHF). Through a dual-phase, non-enzymatic release mechanism, CPT is first released in plasma from XMT-1001 as the lipophilic prodrugs CPT-SI (a succinimidoglycinate derivative) and CPT-SA (a succinamidoyl glycinate derivative), which are then hydrolyzed within tissues to release the lactone form of CPT. CPT inhibits the catalytic activity of DNA topoisomerase I, thereby inhibiting DNA replication and inducing apoptosis. This agent may exhibit a more favorable pharmacokinetic profile than other agents in the same class.NCI
code
  • C69079
http://linked.open...y/mesh/hasConcept
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