About: Pladienolide Derivative E7107     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pladienolide Derivative E7107
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pladienolide Derivative E7107
NCI_META_CUI
  • CL375254
CAS_Registry
  • 630100-90-2
FDA_UNII_Code
  • R60DZX1E2N
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 546981
PDQ_Closed_Trial_Search_ID
  • 546981
Chemical_Formula
  • C40H66N2O9
Legacy_Concept_Name
  • Pladienolide_Derivative_E7107
FULL_SYN
  • E7107PTFDAR60DZX1E2N
  • E7107CNNCI
  • Pladienolide Derivative E7107PTNCI
DEFINITION
  • A synthetic urethane derivative of pladienolide D with potential antineoplastic activity. Pladienolide derivative E7107 is generated from the 12-membered macrolide pladienolide D, one of several macrolides derived from the bacterium Streptomyces platensis Mer-11107. This agent appears to bind to the 130-kDa subunit 3 (spliceosome-associated protein 130; SAP130) of the splicing factor 3b (SF3b), resulting in inhibition of pre-messenger RNA splicing and the arrest of cell-cycle progression. The splicing factor SF3b is a multiprotein complex integral to the accurate excision of introns from pre-messenger RNA; the subunit SAP130 associates with U2 snRNP and is recruited to prespliceosomal complexes.NCI
code
  • C69005
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