About: Abexinostat     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Abexinostat
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Abexinostat
UMLS_CUI
  • C1739653
CAS_Registry
  • 783355-60-2
FDA_UNII_Code
  • IYO470654U
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 553625
PDQ_Closed_Trial_Search_ID
  • 553625
Chemical_Formula
  • C21H23N3O5
Legacy_Concept_Name
  • HDAC_Inhibitor_CRA-024781
FULL_SYN
  • AbexinostatPTNCI
  • HDAC Inhibitor PCI-24781SYNCI
  • 2-benzofurancarboxamide, 3-((dimethylamino)methyl)-n-(2-(4-((hydroxyamino)carbonyl)phenoxy)ethyl)-SNNCI
  • PCI-24781CNNCI
  • CRA-024781PTNCI-GLOSSCDR0000630936
  • ABEXINOSTATPTFDAIYO470654U
  • 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)-1-benzofuran-2-carboxamideSYNCI
  • CRA-024781CNNCI
DEFINITION
  • A broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, this agent has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs).NCI
code
  • C68920
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