About: Piridronic Acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Piridronic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Piridronic Acid
UMLS_CUI
  • C0045686
CAS_Registry
  • 75755-07-6
FDA_UNII_Code
  • ADD4H8T3K9
Contributing_Source
  • FDA
Chemical_Formula
  • C7H11NO6P2
Legacy_Concept_Name
  • Piridronic_Acid
FULL_SYN
  • PIRIDRONIC ACIDPTFDAADD4H8T3K9
  • Piridronic AcidPTNCI
  • 2-(2-Pyridyl)ethylidine-1,1-bisphosphonateSNNCI
DEFINITION
  • A synthetic pyridinyl bisphosphonate with anti-resorptive activity. Although the exact mechanism of action has yet to be fully elucidated, piridronic acid likely binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate synthase, an enzyme that plays an important role in the mevalonate pathway. This inhibits the formation of isoprenoid metabolites that are substrates for protein prenylation. This prevents farnesylation and geranylgeranylation of proteins essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, piridronic acid decreases bone turnover and stabilizes the bone matrix.NCI
code
  • C66420
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