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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ibandronic Acid
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ibandronic Acid
UMLS_CUI
  • C0379200
CAS_Registry
  • 114084-78-5
FDA_UNII_Code
  • UMD7G2653W
Contributing_Source
  • FDA
Chemical_Formula
  • C9H23NO7P2
Legacy_Concept_Name
  • Ibandronic_Acid
FULL_SYN
  • IBANDRONIC ACIDPTFDAUMD7G2653W
  • Ibandronic AcidPTNCI
DEFINITION
  • A third-generation amino-bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Ibandronic acid binds to and adsorbs onto the surface of hydroxyapatite crystals in the bone matrix, thereby preventing osteoclast resorption. This agent also inhibits farnesyl pyrophosphate synthase, an enzyme involved in the mevalonate pathway. Inhibition of this enzyme prevents the formation of isoprenoids, thereby leading to a reduction in the farnesylation and geranylgeranylation of signaling proteins of G protein-coupled signaling, and, eventually, inducing apoptosis of osteoclasts. By inhibiting osteoclast-mediated bone resorption, ibandronic acid increases bone mineral density, decreases bone remodeling and turnover, as well as reduces bone pain.NCI
code
  • C65874
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