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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Auranofin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Auranofin
UMLS_CUI
  • C0699923
CAS_Registry
  • 34031-32-8
FDA_UNII_Code
  • 3H04W2810V
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 710355
PDQ_Closed_Trial_Search_ID
  • 710355
Chemical_Formula
  • C20H34AuO9PS
Legacy_Concept_Name
  • Auranofin
CHEBI_ID
  • CHEBI:2922
FULL_SYN
  • AURANOFINPTFDA3H04W2810V
  • RidauraBRNCI
  • AuranofinPTNCI
DEFINITION
  • An orally available, lipophilic, organogold compound, used to treat rheumatoid arthritis, with anti-inflammatory and potential antineoplastic activities. Auranofin interacts with selenocysteine residue within the redox-active domain of mitochondrial thioredoxin reductase (TrxR), thereby blocking the activity of TrxR. As a result, this agent induces mitochondrial oxidative stress leading to the induction of apoptosis. Furthermore, this agent strongly inhibits the JAK1/STAT3 signal transduction pathway, thereby suppressing expression of immune factors involved in inflammation. TrxR, overexpressed in many cancer cell types, inhibits apoptosis, promotes cell growth and survival and plays a role in resistance to chemotherapy; TrxR catalyzes the reduction of oxidized thioredoxin (Trx) and plays a central role in regulating cellular redox homeostasis.NCI
code
  • C65242
sameAs
http://linked.open...y/mesh/hasConcept
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