About: Lexatumumab

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Lexatumumab
rdfs:subClassOf	Antibodies, Monoclonal nodeID://b686845 nodeID://b686846 nodeID://b686847
Has_Target	Tumor Necrosis Factor Receptor Superfamily Member 10B
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance Immunologic Factor
Preferred_Name	Lexatumumab
UMLS_CUI	C1721684
CAS_Registry	845816-02-6
FDA_UNII_Code	967Q0SJD77
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL-R2 on the surface of some tumor cells, which may kill the tumor cells. HGS-ETR2 is a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID	528015
PDQ_Closed_Trial_Search_ID	528015
Legacy_Concept_Name	Lexatumumab
FULL_SYN	Monoclonal Antibody HGS-ETR2SYNCI LexatumumabPTNCI anti-TRAIL R2 mAb HGS-ETR2PTNCI-GLOSSCDR0000643597 lexatumumabPTNCI-GLOSSCDR0000537263 HGS-ETR2PTNCI-GLOSSCDR0000641121 HGS1018CNNCI Anti-TRAIL Receptor 2 Monoclonal Antibody HGS-ETR2SYNCI HGS-ETR2CNNCI HGS-ETR2SYNCI LEXATUMUMABPTFDA967Q0SJD77
DEFINITION	A fully human monoclonal agonistic antibody directed against tumor necrosis factor-alpha (TNF-alpha)-related apoptosis-inducing ligand receptor-2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural ligand TRAIL, lexatumumab binds to and activates TRAIL-R2, which may trigger apoptosis in and inhibit the growth of TRAIL-R2-expressing tumor cells. TRAIL-R2, also known as death receptor 5 (DR5), is a member of the TNF receptor family and is expressed on many malignant cell types.NCI
code	C64621
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0497980

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