About: 5-Fluoro-2-Deoxycytidine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	5-Fluoro-2-Deoxycytidine
rdfs:subClassOf	Pyrimidine Antagonist nodeID://b725302 nodeID://b725303 nodeID://b725304
Has_Target	DNA
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	5-Fluoro-2-Deoxycytidine
NSC_Code	48006
UMLS_CUI	C0049174
CAS_Registry	10356-76-0
FDA_UNII_Code	KUA4693H5W
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. It may prevent the growth of tumors by stopping cancer cells from dividing and by killing them. It is a type of antimetabolite.NCI-GLOSS
PDQ_Open_Trial_Search_ID	509184
PDQ_Closed_Trial_Search_ID	509184
Chemical_Formula	C9H12FN3O4
Legacy_Concept_Name	_5-Fluoro-2-Deoxycytidine
FULL_SYN	5-fluoro-2-deoxycytidinePTNCI-GLOSSCDR0000528024 5-Fluoro-2-DeoxycytidinePTNCI FdCydPTNCI-GLOSSCDR0000546729 FdCydABNCI Cytidine, 2'-deoxy-5-fluoro-SNNCI 5-FLUORO-2'-DEOXYCYTIDINEPTFDAKUA4693H5W Ro 5-1090CNNCI
DEFINITION	An antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.NCI
code	C62785
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0051113

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