About: Procarbazine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Procarbazine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Procarbazine
UMLS_CUI
  • C0033223
CAS_Registry
  • 671-16-9
FDA_UNII_Code
  • 35S93Y190K
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.NCI-GLOSS
Chemical_Formula
  • C12H19N3O
Legacy_Concept_Name
  • Procarbazine_Base
FULL_SYN
  • PROCARBAZINEPTFDA35S93Y190K
  • ProcarbazinSYNCI
  • BenzethyzinSYNCI
  • ProcarbazinePTNCI
  • IbenzmethyzinSYNCI
  • procarbazinePTNCI-GLOSSCDR0000045378
  • N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamideSNNCI
  • N-4-isopropylcarbamoylbenzyl-N'-methylhydrazineSNNCI
  • N-MethylhydrazineSNNCI
  • N-isopropyl-alpha-(2-methylhydrazino)-p-toluamideSNNCI
  • p-(N'-methylhydrazinomethyl)-N-isopropylbenzamideSNNCI
DEFINITION
  • A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.NCI
code
  • C62072
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Free_Acid_Or_Base_Form of
is sameAs of
Faceted Search & Find service v1.16.121 as of Mar 31 2025


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data]
OpenLink Virtuoso version 07.20.3240 as of Mar 31 2025, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 14 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software