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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Sorafenib
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sorafenib
UMLS_CUI
  • C1516119
CAS_Registry
  • 284461-73-0
In_Clinical_Trial_For
  • Metastatic, androgen-independent prostate cancer
FDA_UNII_Code
  • 9ZOQ3TZI87
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Sorafenib stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
Chemical_Formula
  • C21H16ClF3N4O3
Legacy_Concept_Name
  • Sorafenib
CHEBI_ID
  • CHEBI:50924
FULL_SYN
  • sorafenibPTNCI-GLOSSCDR0000390251
  • SorafenibPTDCP50517
  • SORAFENIBPTFDA9ZOQ3TZI87
  • SorafenibPTNCI
  • BAY 43-9006CNNCI
  • BAY 43-9006PTNCI-GLOSSCDR0000306493
DEFINITION
  • A synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.NCI
code
  • C61948
sameAs
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