About: Polymyxin B1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Polymyxin B1
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Polymyxin B1
UMLS_CUI
  • C0909450
CAS_Registry
  • 4135-11-9
FDA_UNII_Code
  • B35S89JSRU
Contributing_Source
  • FDA
Chemical_Formula
  • C56H98N16O13
Legacy_Concept_Name
  • Polymyxin_B1
CHEBI_ID
  • CHEBI:8309
FULL_SYN
  • Polymyxin B1PTNCI
  • POLYMYXIN B1PTFDAB35S89JSRU
DEFINITION
  • A polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B1 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B1 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.NCI
code
  • C61896
http://linked.open...y/mesh/hasConcept
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