About: Alendronic Acid     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alendronic Acid
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Alendronic Acid
UMLS_CUI
  • C0771311
CAS_Registry
  • 66376-36-1
FDA_UNII_Code
  • X1J18R4W8P
Contributing_Source
  • FDA
Chemical_Formula
  • C4H13NO7P2
Legacy_Concept_Name
  • Alendronic_Acid
CHEBI_ID
  • CHEBI:2567
FULL_SYN
  • AlendronateSYNCI
  • ALENDRONIC ACIDPTFDAX1J18R4W8P
  • Alendronic AcidPTNCI
  • (4-Amino-1-hydroxybutylidene)bisphosphonic AcidSNNCI
  • Alendronic AcidPTDCP50679
DEFINITION
  • A second generation bisphosphonate and synthetic analog of pyrophosphate with anti-bone-resorption activity. Alendronic acid binds to and inhibits the activity of farnesyl pyrophosphate synthetase, an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids, donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which are important in the process of osteoclast turnover. As a result, bone resorption and turnover are reduced.NCI
code
  • C61625
is Has_Free_Acid_Or_Base_Form of
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