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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • IPI-609
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • IPI-609
UMLS_CUI
  • C1881124
Legacy_Concept_Name
  • IPI-609
FULL_SYN
  • IPI-609PTNCI
DEFINITION
  • A novel proprietary small molecule, and a selective inhibitor of sonic hedgehog signaling pathway, with potential anti-tumor activity. The hedgehog signaling pathway is normally active during neuronal development in embryos and quiescent in adult cells. However, aberrant activation of the hedgehog pathway in adults has been implicated in many cancers, including cancers of the pancreas, prostate, lung (small cell), and brain (glioma). IPI-609 exerts its effect through inhibiting the hedgehog signaling pathway and thereby alters gene expressions of the cancer cells.NCI
code
  • C60772
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