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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gentamicin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Carbohydrate
Preferred_Name
  • Gentamicin
PubMedID_Primary_Reference
  • 15690437
NSC_Code
  • 82261
UMLS_CUI
  • C0017436
CAS_Registry
  • 1403-66-3
FDA_UNII_Code
  • T6Z9V48IKG
Contributing_Source
  • FDA
ALT_DEFINITION
  • A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1(subA), obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (TRANSLATION (GENETICS)).MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39250
PDQ_Closed_Trial_Search_ID
  • 39250
Legacy_Concept_Name
  • Gentamicin
CHEBI_ID
  • CHEBI:17833
FULL_SYN
  • Genoptic S.O.P.BRNCI
  • U-GencinSYDTPNSC0082261
  • GenopticSYDTPNSC0082261
  • Gentamycin ComplexSYNCI
  • GaramycinSYDTPNSC0082261
  • GENTAMICINPTFDAT6Z9V48IKG
  • U-GencinBRNCI
  • GenopticBRNCI
  • GaramicinBRNCI
  • GaramycinBRNCI
  • GentamicinPTNCI
  • GentamycinSYNCI
DEFINITION
  • A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.NCI
code
  • C519
sameAs
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