About: Belinostat

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Belinostat
rdfs:subClassOf	Histone Deacetylase Inhibitor nodeID://b701416 nodeID://b701417 nodeID://b701418 nodeID://b701419
Has_Target	Histone Deacetylases
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Belinostat
NSC_Code	726630
UMLS_CUI	C1452684
CAS_Registry	414864-00-9
FDA_UNII_Code	F4H96P17NZ
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of cancer. Belinostat blocks enzymes needed for cell division and may kill cancer cells. It also prevents the growth of blood vessels needed for tumors to grow and may make tumor cells more sensitive to other anticancer drugs. It is a type of histone deacetylase (HDAC) inhibitor, a type of angiogenesis inhibitor, and a type of chemosensitizer.NCI-GLOSS
PDQ_Open_Trial_Search_ID	454583
PDQ_Closed_Trial_Search_ID	454583
Chemical_Formula	C15H14N2O4S
Legacy_Concept_Name	PXD101
CHEBI_ID	CHEBI:61076
FULL_SYN	belinostatPTNCI-GLOSSCDR0000600484 PXD101PTNCI-GLOSSCDR0000486423 PXD101CNNCI PXD 101CNNCI PXD 101PTDCP32043 BELINOSTATPTFDAF4H96P17NZ BelinostatPTNCI
DEFINITION	A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.NCI
code	C48812
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0467681

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