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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Trimethoprim Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Trimethoprim Sulfate
UMLS_CUI
  • C0724713
CAS_Registry
  • 56585-33-2
FDA_UNII_Code
  • E377MF8EQ8
Contributing_Source
  • FDA
Chemical_Formula
  • 2C14H18N4O3.H2SO4
Legacy_Concept_Name
  • Trimethoprim_Sulfate
FULL_SYN
  • 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Sulfate (2:1)SNNCI
  • TRIMETHOPRIM SULFATEPTFDAE377MF8EQ8
  • Trimethoprim SulfatePTNCI
DEFINITION
  • The sulfate salt form of trimethoprim, a synthetic substituted pyrimidine with antibacterial activity. Trimethoprim sulfate selectively binds to and reversibly inhibits dihydrofolate reductase, thereby blocking the production of tetrahydrofolic acid from dihydrofolic acid. This leads to an inhibition of bacterial synthesis of folic acid, thereby affecting nucleic acid and protein synthesis. Trimethoprim sulfate has a stronger binding affinity for the bacterial enzyme than for the corresponding mammalian enzyme.NCI
code
  • C48028
sameAs
is Has_Salt_Form of
is sameAs of
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