About: Ondansetron Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ondansetron Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Ondansetron Hydrochloride
NSC_Code
  • 665799
UMLS_CUI
  • C0700478
CAS_Registry
  • 99614-01-4
Accepted_Therapeutic_Use_For
  • Nausea and vomiting prophylaxis, chemotherapy-induced and postoperative
FDA_UNII_Code
  • NMH84OZK2B
Contributing_Source
  • FDA
ALT_DEFINITION
  • The active ingredient in a drug used to treat nausea and vomiting caused by cancer treatment. It is a type of serotonin receptor antagonist and a type of antiemetic.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 489533
PDQ_Closed_Trial_Search_ID
  • 489533
Chemical_Formula
  • C18H19N3O.HCl.2H2O
Legacy_Concept_Name
  • Ondansetron_Hydrochloride
FULL_SYN
  • ondansetron hydrochloridePTNCI-GLOSSCDR0000616146
  • ZofranSYDTPNSC0665799
  • Ondansetron HydrochloridePTNCI
  • ZofranPTNCI-GLOSSCDR0000413960
  • SN-307CNNCI
  • ZofranBRNCI
  • ONDANSETRON HYDROCHLORIDEPTFDANMH84OZK2B
  • GR 38032FCNNCI
  • GR-C507/75CNNCI
DEFINITION
  • The hydrochloride salt of the racemic form of ondansetron, a carbazole derivative and a selective, competitive serotonin 5-hydroxytrptamine type 3 (5-HT3) receptor antagonist with antiemetic activity. Although its mechanism of action has not been fully characterized, ondansetron appears to competitively block the action of serotonin at 5HT3 receptors peripherally in the gastrointestinal tract as well as centrally in the area postrema of the CNS, where the chemoreceptor trigger zone (CTZ) for vomiting is located, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.NCI
code
  • C48007
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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