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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Zafirlukast
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Zafirlukast
UMLS_CUI
  • C0378466
CAS_Registry
  • 107753-78-6
FDA_UNII_Code
  • XZ629S5L50
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to prevent and treat symptoms of asthma. It blocks substances that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene receptor antagonist.NCI-GLOSS
Chemical_Formula
  • C31H33N3O6S
Legacy_Concept_Name
  • Zafirlukast
CHEBI_ID
  • CHEBI:10100
FULL_SYN
  • ZafirlukastPTNCI
  • zafirlukastPTNCI-GLOSSCDR0000631063
  • ZafirlukastPTDCP20039
  • Carbamic Acid,(3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, Cyclopentyl EsterSNNCI
  • Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamateSNNCI
  • AccolatePTNCI-GLOSSCDR0000631064
  • AccolateBRNCI
  • ZAFIRLUKASTPTFDAXZ629S5L50
DEFINITION
  • A toyl compound with anti-asthmatic property. Zafirlukast selectively and competitively binds and blocks the cysteinyl leukotriene 1 receptor , thereby preventing potent proinflammatory mediators leukotriene C4, D4 and E4 from binding. This prevents leukotriene-mediated actions, including enhanced migration of eosinophils and neutrophils, increased adhesion of leukocytes, increased monocyte and neutrophil aggregation, increased airway edema, inflammation, capillary permeability and bronchoconstriction.NCI
code
  • C47785
sameAs
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