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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Trimethadione
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Trimethadione
NSC_Code
  • 15799
UMLS_CUI
  • C0041038
CAS_Registry
  • 127-48-0
FDA_UNII_Code
  • R7GV3H6FQ4
Contributing_Source
  • FDA
Chemical_Formula
  • C6H9NO3
Legacy_Concept_Name
  • Trimethadione
FULL_SYN
  • TRIMETHADIONEPTFDAR7GV3H6FQ4
  • TrimethadionePTNCI
  • 2,4-Oxazolidinedione, 3,5,5-trimethyl-SNNCI
  • TridioneBRNCI
DEFINITION
  • A dione-type anticonvulsant with antiepileptic activity. Trimethadione reduces T-type calcium currents in thalamic neurons, thereby stabilizing neuronal membranes, raising the threshold for repetitive activities in the thalamus and inhibiting corticothalamic transmission. This decreases the abnormal thalamocortical rhythmicity, which is thought to underlie the paroxysmal three-cycle-per-second spike-and-wave pattern seen with absence (petit mal) seizures.NCI
code
  • C47772
sameAs
http://linked.open...y/mesh/hasConcept
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