About: Proguanil Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Proguanil Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Proguanil Hydrochloride
NSC_Code
  • 12977
  • 26614
UMLS_CUI
  • C0546856
CAS_Registry
  • 637-32-1
FDA_UNII_Code
  • R71Y86M0WT
Contributing_Source
  • FDA
Chemical_Formula
  • C11H16ClN5.HCl
Legacy_Concept_Name
  • Proguanil_Hydrochloride
FULL_SYN
  • ChloriguaneBRNCI
  • 1-(p-Chlorophenyl)-5-isopropylbiguanide HydrochlorideSNNCI
  • Proguanil HydrochloridePTNCI
  • ChlorguanideBRNCI
  • ChloroquanilSYNCI
  • PROGUANIL HYDROCHLORIDEPTFDAR71Y86M0WT
  • Chloroguanide HydrochlorideSYNCI
  • Imidodicarbonimidic Diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Monohydrochloride(9CI)SNNCI
  • BigumalumSYNCI
DEFINITION
  • The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.NCI
code
  • C47690
sameAs
http://linked.open...y/mesh/hasConcept
is Has_Salt_Form of
is sameAs of
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