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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Levetiracetam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Levetiracetam
UMLS_CUI
  • C0377265
CAS_Registry
  • 102767-28-2
Accepted_Therapeutic_Use_For
  • Treating partial-onset seizures in patients with epilepsy.
FDA_UNII_Code
  • 44YRR34555
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat seizures (involuntary muscle movements) caused by epilepsy (a group of brain disorders). Keppra is being studied in the treatment of seizures in patients with cancer that has spread to the brain. It is a type of anticonvulsant.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 526173
PDQ_Closed_Trial_Search_ID
  • 526173
Chemical_Formula
  • C8H14N2O2
Legacy_Concept_Name
  • Levetiracetam
CHEBI_ID
  • CHEBI:6437
FULL_SYN
  • LEVETIRACETAMPTFDA44YRR34555
  • (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamideSNNCI
  • LevetiracetamPTNCI
  • 1-Pyrrolidineacetamide, Alpha-ethyl-2-oxo-,(S)-SNNCI
  • KeppraPTNCI-GLOSSCDR0000556426
  • levetiracetamPTNCI-GLOSSCDR0000533417
  • KeppraBRNCI
DEFINITION
  • A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.NCI
code
  • C47581
sameAs
http://linked.open...y/mesh/hasConcept
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