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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dutasteride
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Dutasteride
UMLS_CUI
  • C0754659
CAS_Registry
  • 164656-23-9
FDA_UNII_Code
  • O0J6XJN02I
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat symptoms of an enlarged prostate gland. It is being studied in the treatment of male hair loss and prostate cancer. Avodart blocks enzymes the body needs to make male sex hormones. It is a type of 5-alpha reductase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 479183
PDQ_Closed_Trial_Search_ID
  • 479183
Chemical_Formula
  • C27H30F6N2O2
Legacy_Concept_Name
  • Dutasteride
CHEBI_ID
  • CHEBI:521033
FULL_SYN
  • DutasteridePTNCI
  • dutasteridePTNCI-GLOSSCDR0000488413
  • GG745PTNCI-GLOSSCDR0000523321
  • Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamideSNNCI
  • DutasteridePTDCP50531
  • alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidideSNNCI
  • GG 745CNNCI
  • AvodartPTNCI-GLOSSCDR0000523319
  • AvodartBRNCI
  • DUTASTERIDEPTFDAO0J6XJN02I
DEFINITION
  • A synthetic 4-azasteroid compound. Dutasteride competitively and specifically binds to isoenzymes 1 and 2 of 5 alpha-reductase, forming stable enzyme complexes and inhibiting the conversion of testosterone to 5 alpha-dihydrotestosterone (DHT); the reduction in DHT activity may mitigate or prevent enlargement of the prostate gland. The type 2 5 alpha-reductase isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also active in skin and the liver.NCI
code
  • C47503
sameAs
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