About: Chlorthalidone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Chlorthalidone
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Chlorthalidone
NSC_Code
  • 69200
UMLS_CUI
  • C0008294
CAS_Registry
  • 77-36-1
FDA_UNII_Code
  • Q0MQD1073Q
Contributing_Source
  • FDA
Chemical_Formula
  • C14H11ClN2O4S
Legacy_Concept_Name
  • Chlorthalidone
CHEBI_ID
  • CHEBI:3654
FULL_SYN
  • CHLORTHALIDONEPTFDAQ0MQD1073Q
  • Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-SNNCI
  • ChlorthalidonePTNCI
  • ChlorphthalidoloneSYNCI
  • ChlorthalidonePTDCP01647
  • HygrotonBRNCI
  • ThalitoneBRNCI
  • Benzenesulfonamide, 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-SNNCI
DEFINITION
  • A long acting thiazide-like diuretic of the sulfamoylbenzamide class and is devoid of the benzothiadiazine structure. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule (DCT) in the kidney. This leads to an increase in sodium, chloride, bicarbonate, and potassium secretion resulting in the excretion of water. In addition, this agent, like other thiazide diuretics, decreases calcium and uric acid secretion. In addition, this agent inhibits many carbonic anhydrase (CA) isoenzymes. Chlorthalidone is used in the treatment of high blood pressure, edema and congestive heart failure. The elimination half-life is about 40 to 50 hours.NCI
code
  • C47449
sameAs
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