About: Platelet Amyloid Precursor Protein Pathway

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About: Platelet Amyloid Precursor Protein Pathway Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Platelet Amyloid Precursor Protein Pathway
rdfs:subClassOf	Homeostasis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Platelet Amyloid Precursor Protein Pathway
UMLS_CUI	C1514160
BioCarta_ID	h_plateletAppPathway
ALT_DEFINITION	The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease. Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP. The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation. Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules. These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage.BIOCARTA
Legacy_Concept_Name	Platelet_Amyloid_Precursor_Protein_Pathway
FULL_SYN	Platelet Amyloid Precursor Protein PathwayPTNCI Platelet Amyloid Precursor Protein PathwayPTBIOCARTA
code	C39191
is someValuesFrom of	nodeID://b642962 nodeID://b645622 nodeID://b654583 nodeID://b660852 nodeID://b660974 nodeID://b671773 nodeID://b699813 nodeID://b699824 nodeID://b699940 nodeID://b703361 nodeID://b719889 nodeID://b722233

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