About: Bone Mineralization Regulation Pathway     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Bone Mineralization Regulation Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Bone Mineralization Regulation Pathway
UMLS_CUI
  • C1511249
BioCarta_ID
  • h_npp1Pathway
ALT_DEFINITION
  • Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific alkaline phosphatase (TNAP) and plasma cell membrane glycoprotein-1 (PC-1) are involved in this process. In the bone matrix, PC-1 is the major producer of PPi, which in turn has an inhibitory effect on hydroxyapatite deposition. TNAP has a positive influence on mineralization primarily by controlling the size of the inhibitory pool of PPi through its inorganic pyrophosphatase activity. TNAP also generates Pi by using NTPs and PPi as substrates, but other more major sources of Pi e.g., intestinal absorption, are likely to contribute the bulk of the Pi needed for hydroxyapatite deposition.BIOCARTA
Legacy_Concept_Name
  • Bone_Mineralization_Regulation_Pathway
FULL_SYN
  • Regulators of Bone MineralizationPTBIOCARTA
  • Bone Mineralization Regulation PathwayPTNCI
code
  • C39172
is someValuesFrom of
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