About: Transforming Growth Factor-Beta-Induced Protein IG-H3     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Transforming Growth Factor-Beta-Induced Protein IG-H3
rdfs:subClassOf
OMIM_Number
  • 601692
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Transforming Growth Factor-Beta-Induced Protein IG-H3
UMLS_CUI
  • C0172642
Legacy_Concept_Name
  • Transforming_Growth_Factor-Beta_Induced_Protein-IGH3
FULL_SYN
  • Transforming Growth Factor-Beta-Induced Protein IG-H3PTNCI
  • Transforming Growth Factor Beta-Induced 68kDa ProteinSYNCI
  • KeratoepithelinSYNCI
  • RGD-CAPSYNCI
  • Beta IGH3SYNCI
  • RGD-Containing Collagen Associated ProteinSYNCI
Swiss_Prot
  • Q15582
DEFINITION
  • Transforming growth factor-beta-induced protein IG-H3 precursor (683 aa, 75 kD) is a cellular division process protein that is encoded by the human TGFBI gene and has roles in negative regulation of cell adhesion, visual perception and cell proliferation.NCI
DesignNote
  • Constitutively expressed by human TGFBI Gene in many tissues (high in corneal epithelium) and TGF-beta induced, highly conserved 683-aa 75-kDa (precursor) extracellular Transforming Growth Factor-Beta Induced Protein IGH3 contains an N-signal peptide, four 140-aa FAS1 domains with internal homology, and a C-RGD motif. RGD is found in many extracellular matrix proteins that modulate cell adhesion and serves as a ligand recognition sequence for several integrins. With similar structure to fasciclin I (putative neuronal cell adhesion protein) and OSF-2 (potential bone adhesion protein), TGFBI binds to types I, II, and IV collagens. A potential adhesion protein, TGFBI may play role in cell-collagen interactions, may be associated with microfibrils and the cell surface, and may be involved in endochondral bone formation. TGFBI defects cause CDGG1, CDRB, CDL1, CDL3A, and ACD. (NCI)
code
  • C38672
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