About: 5-Hydroxypicolinaldehyde Thiosemicarbazone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • 5-Hydroxypicolinaldehyde Thiosemicarbazone
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • 5-Hydroxypicolinaldehyde Thiosemicarbazone
NSC_Code
  • 107392
UMLS_CUI
  • C1521421
Legacy_Concept_Name
  • _5-Hydroxypicolinaldehyde_Thiosemicarbazone
FULL_SYN
  • 5-Hydroxypicolinaldehyde ThiosemicarbazonePTNCI
  • 5-HPABNCI
DEFINITION
  • A thiosemicarbazone antimetabolite. A derivative of 5-hydroxypicolinaldehyde, 5-HP inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. (NCI04)NCI
DesignNote
  • Inhibits DNA synthesis by preventing incorporation of thymidine into DNA (chelates iron)
code
  • C38468
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