About: Alvespimycin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alvespimycin
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Alvespimycin
NSC_Code
  • 707545
UMLS_CUI
  • C1527262
CAS_Registry
  • 467214-20-6
In_Clinical_Trial_For
  • Solid Tumors; Lymphomas; Metastatic or Unresectable Solid Tumors.
FDA_UNII_Code
  • 001L2FE0M3
Contributing_Source
  • FDA
ALT_DEFINITION
  • 17-DMAG. A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called geldanamycin analogs.NCI-GLOSS
Chemical_Formula
  • C32H48N4O8
Legacy_Concept_Name
  • _17-Dimethylaminoethylamino_17-Demethoxygeldanamycin
FULL_SYN
  • ALVESPIMYCINPTFDA001L2FE0M3
  • AlvespimycinPTNCI
  • 17-DMAGABNCI
  • Geldanamycin,17-demethoxy-17-((2-(dimethylamino)ethyl)amino)-SNNCI
  • 17-(Dimethylaminoethylamino)-17-DemethoxygeldanamycinSYNCI
  • 17-dimethylaminoethylamino-17-demethoxygeldanamycinPTNCI-GLOSSCDR0000455147
DEFINITION
  • An analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.NCI
code
  • C38142
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