About: Tanespimycin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tanespimycin
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Tanespimycin
NSC_Code
  • 330507
UMLS_CUI
  • C0675974
CAS_Registry
  • 75747-14-7
Accepted_Therapeutic_Use_For
  • Chronic Myelogenous Leukemia
In_Clinical_Trial_For
  • Progressive metastatic prostate cancer; chronic myelogenous leukemia; unresectable; refractory; or advanced solid tumors; advanced epithelial cancer; malignant lymphoma; advanced sarcoma; advanced hematologic cancers.
FDA_UNII_Code
  • 4GY0AVT3L4
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is made from an antibiotic called geldanamycin. Tanespimycin helps cause the breakdown of certain proteins in the cell, and may kill cancer cells. It is a type of antineoplastic antibiotic and a type of HSP90 inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43635
PDQ_Closed_Trial_Search_ID
  • 43635
Chemical_Formula
  • C31H43N3O8
Legacy_Concept_Name
  • _17-Allylamino_17-demethoxygeldanamycin
CHEBI_ID
  • CHEBI:64153
FULL_SYN
  • TANESPIMYCINPTFDA4GY0AVT3L4
  • 17-Demethoxy-17-(2-propenylamino)geldanamycinPTDCP50023
  • TanespimycinPTNCI
  • Geldanamycin, 17-allylamino-17-demethoxy-SYDTPNSC0330507
  • 17-AAGSYDTPNSC0330507
  • 17-Demethoxy-17-(2-propenylamino)geldanamycinSNNCI
  • tanespimycinPTNCI-GLOSSCDR0000617667
  • 17-AAGPTNCI-GLOSSCDR0000518652
  • 17-Allylamino-17-demethoxygeldanamycinSNNCI
  • 17-AAGABNCI
  • 17-N-allylamino-17-demethoxy geldanamycinSYNCI-GLOSSCDR0000046745
  • KOS-953BRNCI
  • 17-(Allylamino)-17-demethoxygeldanamycinSYNCI
  • 17-N-allylamino-17-demethoxygeldanamycinSNNCI
DEFINITION
  • A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin. Tanespimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90). HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells.NCI
code
  • C37899
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