About: Protein Phosphatase Regulatory Protein

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

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rdf:type	Class
rdfs:label	Protein Phosphatase Regulatory Protein
rdfs:subClassOf	Regulatory Protein nodeID://b705474 nodeID://b705475 nodeID://b705476
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Protein Phosphatase Regulatory Protein
UMLS_CUI	C1335548
Legacy_Concept_Name	Protein_Phosphatase_Regulatory_Protein
FULL_SYN	Protein Phosphatase Regulatory Protein SubunitSYNCI Protein Phosphatase Regulatory ProteinPTNCI
DEFINITION	A subunit of protein phosphatase 2A that serves as a scaffold for the formation and localization of the holoenzyme complex and plays a role in the modulation of substrate specificity.NCI
DesignNote	A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.
code	C34083
is rdf:first of	nodeID://b741295 nodeID://b741296 nodeID://b741297 nodeID://b741298 nodeID://b741299 nodeID://b741300 nodeID://b741301 nodeID://b741302 nodeID://b741303

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