About: Glioblastoma

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Glioblastoma
equivalentClass	nodeID://b633215
Concept_In_Subset	NCI CTEP Simplified Disease Classification Terminology NCI CTEP SDC Astrocytoma, High Grade Sub-Category Terminology
Semantic_Type	Neoplastic Process
Preferred_Name	Glioblastoma
UMLS_CUI	C0017636
Contributing_Source	CTEP
ALT_DEFINITION	A fast-growing type of central nervous system tumor that forms from glial (supportive) tissue of the brain and spinal cord and has cells that look very different from normal cells. GBM usually occurs in adults and affects the brain more often than the spinal cord.NCI-GLOSS
ICD-O-3_Code	9440/3
Neoplastic_Status	Malignant
Legacy_Concept_Name	Glioblastoma
FULL_SYN	glioblastoma multiformePTNCI-GLOSSCDR0000045699 GBMPTNCI-GLOSSCDR0000539131 Glioblastoma MultiformeSYNCI GlioblastomaPTNCI Grade IV Astrocytic TumorSYNCI GlioblastomaSYNCITCGA glioblastomaPTNCI-GLOSSCDR0000045698 Spongioblastoma MultiformeSYNCI grade IV astrocytomaPTNCI-GLOSSCDR0000044407 Glioblastoma multiformePTCTEP10018337 Grade IV Astrocytic NeoplasmSYNCI GBM (Glioblastoma)SYNCI
DEFINITION	The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO)NCI
code	C3058
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0009269
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is sameAs of	Glioblastoma

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