About: snRNP Structural Core Protein     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • snRNP Structural Core Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • snRNP Structural Core Protein
UMLS_CUI
  • C1337055
Legacy_Concept_Name
  • snRNP_Structural_Core_Protein
FULL_SYN
  • Small Nuclear Ribonucleoprotein Particle Structural Core ProteinSYNCI
  • snRNP Structural Core ProteinPTNCI
  • Sm ProteinSYNCI
DEFINITION
  • The 4 major small nuclear ribonucleoprotein particles (snRNPs), U1, U2, U4/U6, and U5, are essential components of the eukaryotic pre-mRNA splicing machinery. These snRNPs share 8 proteins which form the snRNP structural core: SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG. These common proteins play an essential role in the biogenesis of the snRNPs. The assembly of the common proteins onto the small nuclear RNA (snRNA) appears to occur in at least 2 steps and involves the formation of RNA-free protein heterooligomers. The common proteins are referred to as Sm proteins because they represent the major targets for the anti-Sm autoantibodies which are diagnostic for SLE. (from OMIM and Swiss-Prot)NCI
code
  • C30090
is rdf:first of
is someValuesFrom of
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