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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Azathioprine
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • Azathioprine
NSC_Code
  • 39084
UMLS_CUI
  • C0004482
CAS_Registry
  • 446-86-6
FDA_UNII_Code
  • MRK240IY2L
Contributing_Source
  • FDA
ALT_DEFINITION
  • An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)MSH2002_06_01
Chemical_Formula
  • C9H7N7O2S
Legacy_Concept_Name
  • Azathioprine
CHEBI_ID
  • CHEBI:2948
FULL_SYN
  • AZATHIOPRINEPTFDAMRK240IY2L
  • 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purineSNNCI
  • 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purinePTDCP00948
  • AzathioprinePTNCI
  • AzathioprineSYNCITCGA
  • AZAABNCI
  • AZTPABNCI
DEFINITION
  • A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). 6-MP is further metabolized by hypoxanthine-guanine phosphoribosyltransferase (HGPRT) into 6-thioguanosine-5'-phosphate (6-thio-GMP) and 6-thioinosine monophosphate (6-thio-IMP), both inhibit nucleotide conversions and de novo purine synthesis. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes.NCI
code
  • C290
sameAs
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