About: JAW1-Related Protein     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • JAW1-Related Protein
rdfs:subClassOf
OMIM_Number
  • 604673
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • JAW1-Related Protein
UMLS_CUI
  • C0767190
Legacy_Concept_Name
  • JAW1-Related_Protein
FULL_SYN
  • MRVI1SYNCI
  • JAW1-Related ProteinPTNCI
  • Inositol 1,4,5-triphosphate-associated cGMP Kinase SubstrateSYNCI
DEFINITION
  • The gene encoding this protein is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. This protein is an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM)NCI
code
  • C28521
http://linked.open...y/mesh/hasConcept
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