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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pyroxamide
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pyroxamide
NSC_Code
  • 696085
UMLS_CUI
  • C0966748
CAS_Registry
  • 382180-17-8
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called histone deacetylase inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 256405
PDQ_Closed_Trial_Search_ID
  • 256405
Legacy_Concept_Name
  • Pyroxamide
FULL_SYN
  • pyroxamidePTNCI-GLOSSCDR0000269426
  • PyroxamidePTDCP31781
  • Suberoyl-3-aminopyridineamide Hydroxamic AcidSNNCI
  • PyroxamideSYDTPNSC0696085
  • PyroxamidePTNCI
DEFINITION
  • A synthetic derivative of hydroxamic acid with antineoplastic properties, Pyroxamide inhibits histone deacetylases involved in transcription; induces hyperacetylation of core histones, modulating chromatin structure and affecting transcription of some genes that inhibit tumor growth; and induces growth arrest and apoptosis. Pyroxamide is used in clinical studies for cancer chemotherapy. (NCI04)NCI
code
  • C2801
http://linked.open...y/mesh/hasConcept
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