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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Ziv-Aflibercept
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Immunologic Factor
Preferred_Name
  • Ziv-Aflibercept
NSC_Code
  • 724770
UMLS_CUI
  • C1134659
CAS_Registry
  • 862111-32-8
FDA_UNII_Code
  • 15C2VL427D
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. Vascular endothelial growth factor trap blocks the action of vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38652
PDQ_Closed_Trial_Search_ID
  • 38652
Legacy_Concept_Name
  • VEGF_Trap
FULL_SYN
  • VEGF-TrapPTDCP50707
  • AfliberceptSYNCI
  • afliberceptSYNCI-GLOSSCDR0000597249
  • VEGF Trap R1R2SYNCI
  • Ziv-AfliberceptPTNCI
  • vascular endothelial growth factor trapPTNCI-GLOSSCDR0000597250
  • EyleaBRNCI
  • AVE0005SYNCI
  • Vascular Endothelial Growth Factor TrapSYNCI
  • ZaltrapBRNCI
  • VEGF TrapPTNCI-GLOSSCDR0000256544
  • AFLIBERCEPTPTFDA15C2VL427D
DEFINITION
  • A recombinant protein comprised of epitopes of the extracellular domains of human vascular endothelial growth factor receptors (VEGFR) fused to the constant region (Fc) of human IgG1 with potential antiangiogenic activity. Afilbercept, functioning as a soluble decoy receptor, binds to pro-angiogenic vascular endothelial growth factors (VEGFs), thereby preventing VEGFs from binding to their endogenous receptors. Disruption of the binding of VEGFs to their cellular receptors may result in the inhibition of tumor angiogenesis, metastasis, and ultimately tumor regression.NCI
code
  • C2682
sameAs
http://linked.open...y/mesh/hasConcept
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