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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tarenflurbil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tarenflurbil
NSC_Code
  • 685699
UMLS_CUI
  • C1527219
CAS_Registry
  • 51543-40-9
In_Clinical_Trial_For
  • Localized Prostate Cancer and Alzheimer's disease.
FDA_UNII_Code
  • 501W00OOWA
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 257154
PDQ_Closed_Trial_Search_ID
  • 257154
Chemical_Formula
  • C15H13FO2
Legacy_Concept_Name
  • R-flurbiprofen
CHEBI_ID
  • CHEBI:38666
FULL_SYN
  • TARENFLURBILPTFDA501W00OOWA
  • (R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic AcidSNNCI
  • TarenflurbilPTNCI
  • R-flurbiprofenSYNCI
  • E-7869CNNCI
  • R-flurbiprofenPTNCI-GLOSSCDR0000269427
  • R-FlurbiprofenPTDCP09219
  • MPC-7869CNNCI
  • FlurizanBRNCI
DEFINITION
  • An orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. R-flurbiprofen does not inhibit the enzyme cyclo-oxygenase.NCI
code
  • C26666
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