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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Edotecarin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Edotecarin
UMLS_CUI
  • C1328673
CAS_Registry
  • 174402-32-5
In_Clinical_Trial_For
  • Colorectal Cancer; Esophageal Cancer; Other Solid Tumors.
FDA_UNII_Code
  • 1V8X590XDP
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. It is a type of topoisomerase I inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38537
PDQ_Closed_Trial_Search_ID
  • 38537
Chemical_Formula
  • C29H28N4O11
Legacy_Concept_Name
  • Edotecarin
FULL_SYN
  • edotecarinPTNCI-GLOSSCDR0000334457
  • J-107088PTNCI-GLOSSCDR0000045074
  • EDOTECARINPTFDA1V8X590XDP
  • J-107088CNNCI
  • 6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-dihydro-13-(beta-D-gluco pyranosyl)-5H-indolo[2,3-a]-pyrrolol[3,4-c]-carbazole-5,7(6H)-dioneSNNCI
  • EdotecarinPTNCI
DEFINITION
  • A synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. (NCI04)NCI
code
  • C2665
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