About: Clofarabine

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About: Clofarabine Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Clofarabine
rdfs:subClassOf	Purine Antagonist Ribonucleotide Reductase Inhibitor
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Clofarabine
NSC_Code	606869
UMLS_CUI	C0092777
CAS_Registry	123318-82-1
Accepted_Therapeutic_Use_For	Acute lymphoblastic leukemia, pediatric
In_Clinical_Trial_For	Acute and chronic myeloid leukemia; Acute and chronic lymphoblastic leukemia; Myelodysplastic syndrome; Non-Hodgkin's lymphoma
FDA_UNII_Code	762RDY0Y2H
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat certain types of acute lymphoblastic leukemia in children. It is also being studied in the treatment of other types of cancer. Clolar is a type of nucleoside analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID	257309
PDQ_Closed_Trial_Search_ID	257309
Chemical_Formula	C10H11ClFN5O3
Legacy_Concept_Name	Clofarabine
CHEBI_ID	CHEBI:47311 CHEBI:681569
FULL_SYN	2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenineSNNCI ClofarabinePTNCI clofarabinePTNCI-GLOSSCDR0000269414 ClofarabinePTDCP50526 ClolarPTNCI-GLOSSCDR0000470246 ClolarBRNCI ClofarexBRNCI ClofarexSYNCI CLOFARABINEPTFDA762RDY0Y2H 2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amineSNNCI
DEFINITION	A second generation purine nucleoside analog with antineoplastic activity. Clofarabine is phosphorylated intracellularly to the cytotoxic active 5'-triphosphate metabolite, which inhibits the enzymatic activities of ribonucleotide reductase and DNA polymerase, resulting in inhibition of DNA repair and synthesis of DNA and RNA. This nucleoside analog also disrupts mitochondrial function and membrane integrity, resulting in the release of pre-apoptotic factors, including cytochrome C and apoptotic-inducing factors, which activate apoptosis.NCI
code	C26638
sameAs	CLOFARABINE CLOFARABINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0186928
is someValuesFrom of	nodeID://b660795 nodeID://b660797 nodeID://b660800
is sameAs of	CLOFARABINE CLOFARABINE CLOFARABINE

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