About: Taurolidine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Taurolidine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
Preferred_Name
  • Taurolidine
UMLS_CUI
  • C0144567
CAS_Registry
  • 19388-87-5
Accepted_Therapeutic_Use_For
  • Bronchiectasis; Catheter-Related Sepsis; Otitis Media; Peritonitis; Thoracic Empyema
In_Clinical_Trial_For
  • After Positive Second-Look Surgery in Patients with Recurrent Ovarian; Fallopian Tube; or Primary Peritoneal Cancer and Recurrent or Progressive High-Grade Glioma.
FDA_UNII_Code
  • 8OBZ1M4V3V
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called anti-infectives.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38354
PDQ_Closed_Trial_Search_ID
  • 38354
Chemical_Formula
  • C7H16N4O4S2
Legacy_Concept_Name
  • Taurolidine
FULL_SYN
  • TaurolidinePTNCI
  • taurolidinePTNCI-GLOSSCDR0000045033
  • TaurolinFBNCI
  • Bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methaneSNNCI
  • TAUROLIDINEPTFDA8OBZ1M4V3V
DEFINITION
  • A synthetic broad-spectrum antibiotic with antibacterial, anticoagulant and potential antiangiogenic activities. Taurolidine, derived from the amino acid taurine, binds to and neutralizes bacterial exotoxins and endotoxins, or lipopolysaccharides (LPS). Taurolidine binding to LPS prevents bacterial adherence to host epithelial cells, thereby prevents bacterial invasion of uninfected host cells. Although the mechanism underlying its antineoplastic activity has not been fully elucidated, it may be related to this agent's anti-adherence property. In addition, taurolidine also promotes apoptosis by inducing various apoptotic factors and suppresses the production of vascular endothelial growth factor (VEGF), a protein that plays an important role in angiogenesis.NCI
code
  • C2639
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