About: Paclitaxel Liposome     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Paclitaxel Liposome
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Paclitaxel Liposome
UMLS_CUI
  • C0935868
In_Clinical_Trial_For
  • Breast Cancer; Ovarian Cancer; Non-small Cell Lung Cancer; Locally Advanced or Metastatic Esophageal Carcinoma.
ALT_DEFINITION
  • A form of the anticancer drug paclitaxel that is contained in very tiny, fat-like particles. It may have fewer side effects and work better than paclitaxel. It is being studied in the treatment of several types of cancer. Paclitaxel liposome blocks the ability of cells to divide and may kill cancer cells. It is a type of mitotic inhibitor and a type of antimicrotubule agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38323
PDQ_Closed_Trial_Search_ID
  • 38323
Legacy_Concept_Name
  • Paclitaxel_Liposome
FULL_SYN
  • Liposome-Encapsulated PaclitaxelSYNCI
  • paclitaxel liposomePTNCI-GLOSSCDR0000423263
  • liposomal paclitaxelPTNCI-GLOSSCDR0000663505
  • LEP-ETUPTNCI-GLOSSCDR0000423261
  • PNU-93914PTNCI-GLOSSCDR0000046527
  • Paclitaxel LiposomePTNCI
  • LipoTaxenPTNCI-GLOSSCDR0000663507
DEFINITION
  • A liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds to tubulin and interferes with the assembly/disassembly dynamics of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel liposome formulation potentially enhances delivery of higher doses of paclitaxel to the target tissues and exhibits lower systemic toxicity.NCI
code
  • C2631
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