About: OVA BiP Peptide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • OVA BiP Peptide
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • OVA BiP Peptide
UMLS_CUI
  • C0879487
In_Clinical_Trial_For
  • HLA-A2 Positive Patients with Stage III or IV Melanoma.
PDQ_Open_Trial_Search_ID
  • 37946
PDQ_Closed_Trial_Search_ID
  • 37946
Legacy_Concept_Name
  • OVA_BiP_Peptide
FULL_SYN
  • OVA-BiP Hybrid PeptideSYNCI
  • OVA BiP PeptidePTNCI
DEFINITION
  • A 19 amino-acid hybrid peptide antigen with immune adjuvant property. OVA-BiP peptide consists of 8 amino acids from ovalbumin joined via a tripeptide linker to a stretch of 8 amino acids, the minimum binding domain of BiP (immunoglobulin heavy chain-binding protein, aka grp78), a member of the heat shock protein (hsp) 70 family. As a chaperon, BiP binds to newly synthesized, unfolded mu immnoglobulin heavy chains prior to its assembly with light chains in the endoplasmic reticulum. In conjunction with a tumor antigen, this hybrid peptide is used to potentiate antigen presentation and consequently prime cytotoxic T lymphocyte responses.NCI
code
  • C2546
is someValuesFrom of
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