About: Aminocamptothecin Colloidal Dispersion     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Aminocamptothecin Colloidal Dispersion
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Clinical Drug
Preferred_Name
  • Aminocamptothecin Colloidal Dispersion
UMLS_CUI
  • C0677807
In_Clinical_Trial_For
  • Refractory or Relapsed Leukemia; Solid Tumors; Cancer Predominantly Confined to the Peritoneal Cavity.
PDQ_Open_Trial_Search_ID
  • 42874
PDQ_Closed_Trial_Search_ID
  • 42874
Legacy_Concept_Name
  • Aminocamptothecin_Colloidal_Dispersion
FULL_SYN
  • 9AC colloidal dispersionSYNCI
  • Aminocamptothecin Colloidal DispersionPTNCI
  • 9-aminocamptothecin colloidal dispersionSYNCI
DEFINITION
  • A colloidal dispersion formulation of 9-Aminocamptothecin, a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity.NCI
code
  • C2452
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