About: L-Leucyl-L-Leucine Methyl Ester     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz:8890 associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • L-Leucyl-L-Leucine Methyl Ester
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • L-Leucyl-L-Leucine Methyl Ester
UMLS_CUI
  • C0281255
CAS_Registry
  • 13022-42-9
PDQ_Open_Trial_Search_ID
  • 41645
PDQ_Closed_Trial_Search_ID
  • 41645
Legacy_Concept_Name
  • L-Leucyl-L-Leucine_Methyl_Ester
FULL_SYN
  • LLMEABNCI
  • L-Leucyl-L-Leucine Methyl EsterPTNCI
  • LeuLeuOMeSYNCI
DEFINITION
  • A 2-amino acid compound with immunomodulatory activity. L-leucyl-L-leucine methyl ester (LLME) is a lysosomotropic agent entering cells via receptor-mediated endocytosis. LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. Condensation of LLME leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T-cells and natural killer cells. Therefore, this agent may be able to decrease the incidence of graft versus host disease (GVHD) via cytotoxic T-cell depletion. Furthermore, LLME has the potential in augmenting antibody production when used in pretreatment of peripheral blood mononuclear cells (PBMCs), possibly via interfering gene expressions of inflammatory factors.NCI
code
  • C2377
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